Will Trey Benson play against the Tennessee Titans today? Latest injury update on the Arizona Cardinals running back

The Arizona Cardinals are dealing with a depleted backfield heading into their Week 5 matchup against the Tennessee Titans . After already losing James Conner for the season due to a foot injury, the team will now also be without rookie running back Trey Benson, who has been placed on injured reserve with a knee issue. Benson sustained a meniscus injury during Arizona’s Week 4 game against the Seattle Seahawks. He underwent arthroscopic surgery and is expected to be sidelined for at least four weeks. With Conner already out and Benson now joining him on the sidelines, the Cardinals are left to rely on a committee approach led by Emari Demercado, Michael Carter, and Bam Knight.
Cardinals vs. Titans matchup preview | Sunday, October 5, 2025

• Time: 4:05 PM ET / 1:05 PM PT
• Venue: State Farm Stadium , Glendale, Arizona
• Where to Watch: CBS (national broadcast)

Arizona backfield now belongs to Demercado, Carter, and KnightTrey Benson was expected to step in as Arizona’s lead back after James Conner’s injury, but he’s now on injured reserve with a knee issue. With both out, the Cardinals will likely rotate between Michael Carter, Emari Demercado, and Bam Knight. The Cardinals have no choice but to turn to backups. Emari Demercado is expected to lead the group, with Michael Carter and Bam Knight also getting carries. None of them have handled a full workload yet this season, so the team may rely more on Kyler Murray and quick passes to keep the offense moving. Carter could see early-down work, Demercado may handle passing downs, and Knight adds depth. With no clear lead back, quarterback Kyler Murray may have to take on a lot more responsibility to keep the offense moving.
Can Tennessee exploit Arizona’s injuries and win its first game?
The Tennessee Titans enter Sunday’s game with a winless 0-4 record, and they will look to exploit the Cardinals’ injury-riddled offense. Arizona, sitting at 2-2, will need to find ways to stay balanced despite its lack of depth in the run game.
The Titans' defense could look to force obvious passing situations, dialing up pressure and testing Arizona’s now-reshuffled offensive line. Forcing turnovers, managing the clock, and taking advantage of red-zone opportunities will be the key for Tennessee to pull off a road win and finally get into the win column.
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The Cardinals face a tough challenge without key running backs. Kyler Murray must lead the offense against a hungry Titans defense.